段东柱
1. 基本信息
段东柱，男，汉族，1984年10月生，甘肃通渭县人，博士，副教授，硕士研究生导师。2008年毕业于陇东学院生物科学专业，获理学学士学位；2011年毕业于兰州理工大学微生物与生化药学专业，获理学硕士学位；2014年毕业于兰州大学有机化学专业，获理学博士学位；2014年8月至2015年7月，任职于贵州医科大学基础医学院；2015年7月进入宝鸡文理学院化学化工学院工作至今。
2. 研究方向
1) 药物化学生物学。
2) 生化药理学。
3. 开设课程
承担了《天然药物化学》、《有机化学实验》、《物理化学实验》、《科技论文写作与文献检索》和《化学专业英语》等课程的教学。
4. 主持科研项目（近期代表性5项）
1) 国家自然科学基金面上项目，五味子三萜逆转HECTD3泛素化修饰p62诱导自噬促进三阴性乳腺癌细胞耐药的研究，57万，2021年1月-2024年12月，82073316
2) 陕西省科技厅项目，以TrxR和Hsp90为双靶点的抗肿瘤成分发现及作用机理，3万，2018年1月-2019年12月，2018JQ2051。
3) 陕西省教育厅重点项目，基于两种秦岭特色药用植物的硫氧还蛋白还原酶抑制剂的发现及抗肿瘤机制研究，5万，2016年1月-2017年12月，16JS009。
5. 发表论文
1) Dongzhu Duan*, Yanru Wang, Dabo Pan, Xiaojie Jin, Yunyun Yan, Peng Song, Le Wang, Jian Xiao, Zihua Wang*, Xiaoling Wang*. Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo. Bioorganic Chemistry, 2022, 122:105711. (SCI, IF=5.307)
2) Dongzhu Duan*, Xiaolu Feng, Dabo Pan, Le Wang, Yanru Wang, Xiaoling Wang*. Oridonin induces oxidative stress-mediated cancer cells apoptosis via targeting thioredoxin reductase. Current Pharmaceutical Biotechnology, 2022, 23:1647-1657. (SCI, IF=2.829)
3) Dongzhu Duan*, Yanru Wang, Xiaojie Jin, Mi Li, Le Wang, Yunyun Yan, Jian Xiao, Peng Song*, Xiaoling Wang*. Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells. Free Radical Biology and Medicine, 2021, 177:15-23. (SCI, IF=8.101)
4) Dongzhu Duan*, Yanru Wang, Dabo Pan, Le Wang, Jian Xiao, Peng Song*, Xiaojie Jin, Xiaoling Wang*. Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis. Archives of Biochemistry and Biophysics, 2021, 711:109028. (SCI, IF=4.114)
5) Junmin Zhang1, Dongzhu Duan1, Alsiddig Osama, Jianguo Fang*. Natural molecules targeting thioredoxin system and their therapeutic potentials. Antioxidants & Redox Signaling, 2021, 34:1083-1107. (1Co-first author, SCI, IF=8.401)
6) Maobo Huang1, Yuanfei Zhou1, Dongzhu Duan1, Chuanyu Yang, Zhongmei Zhou, Fubing Li, Yanjie Kong, Yi-Ching Hsieh, Ruihan Zhang, Wenping Ding, Weilie Xiao, PemaTenzin Puno*, Ceshi Chen*. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib. Cancer Letters, 2021, 504:125-136. (1Co-first author, SCI, IF=9.756)
7) Junmin Zhang, Dongzhu Duan, Zi-Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang*. Small molecules regulating reactive oxygen species homeostasis for cancer therapy. Medicinal Research Reviews, 2021, 41: 342-394. (SCI, IF=12.944)
8) Junmin Zhang, Dongzhu Duan, Jianqiang Xu, Jianguo Fang*. A redox-dependentcopper carrier promotes cellular copper uptake and oxidative stress-mediatedapoptosis of cancer cells. ACS Applied Materials & Interfaces, 2018, 39:33010-33021. (SCI, IF=10.383)
9) Dongzhu Duan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang* Targeting thioredoxin reductase by parthenolide Contributes to inducing apoptosis of HeLa cells. Journal of Biological Chemistry, 2016, 291:10021-10031. (SCI, IF=5.157)
10) Dongzhu Duan, Baoxing Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge, Shoujiao Peng, Jianguo Fang*. Gambogic acid inducing apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free Radical Biology and Medicine, 2014, 69:15-25. (SCI, IF=8.101)
11) Dongzhu Duan, Baoxing Zhang, Juan Yao, Yaping Liu, Jianguo Fang*. Shikonin targeting the cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells. Free Radical Biology and Medicine, 2014, 70:182-193. (SCI, IF=8.101)
12) Liangwei Zhang, Dongzhu duan, Yaping Liu, Chunpo Ge, Jinyu Sun, Xuemei Cui, Jianguo Fang*. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in Living Cells. Journal of the American Chemical Society, 2014, 136: 226-233. (SCI, IF=16.383)
6. 联系方式
通讯地址：宝鸡市高新大道1号 宝鸡文理学院化学化工学院
邮编：721013
E-mail: duandongzhu@126.com
