1. 基本信息
段东柱，男，汉族，1984年10月生，甘肃通渭县人，博士，讲师，硕士研究生导师。2008年毕业于陇东学院生物科学专业，获理学学士学位；2011年毕业于兰州理工大学微生物与生化药学专业，获理学硕士学位；2014年毕业于兰州大学有机化学专业，获理学博士学位；2014年8月至2015年7月，任职于贵州医科大学基础医学院；2018年至2019年，作为访问学者在中国科学院昆明动物所进行肿瘤生物学研究；已在包括J. Biol. Chem., Free Radic. Biol. Med., Bioorg. Chem., J. Am. Chem. Soc., Med. Res. Rev., Cancer Lett., J. Med. Chem.等化学与生物医学国际主流SCI期刊发表学术论文40余篇，被引用1500余次，H指数为20；2015年7月进入宝鸡文理学院化学化工学院工作至今。
2. 研究方向
1) 药物化学生物学。
2) 生化药理学。
3. 开设课程
承担了《天然药物化学》、《有机化学实验》、《物理化学实验》、《科技论文写作与文献检索》和《化学专业英语》等课程的教学。
4. 主持科研项目
1) 国家自然科学基金面上项目，五味子三萜逆转HECTD3泛素化修饰p62诱导自噬促进三阴性乳腺癌细胞耐药的研究，经费57万，2021年1月-2024年12月，项目编号82073316。
（项目负责人）
2) 陕西省科技厅项目，以TrxR和Hsp90为双靶点的抗肿瘤成分发现及作用机理，经费3万，2018年1月-2019年12月，项目编号2018JQ2051。（项目负责人）
3) 陕西省教育厅重点项目，基于两种秦岭特色药用植物的硫氧还蛋白还原酶抑制剂的发现
及抗肿瘤机制研究，经费5万，2016年1月-2017年12月，项目编号16JS009。（项目负责人）
5. 发表论文
1) Dongzhu Duan*, Yanru Wang, Dabo Pan, Xiaojie Jin, Yunyun Yan, Peng Song, Le Wang, Jian Xiao, Zihua Wang*, Xiaoling Wang*. Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo. Bioorganic Chemistry, 2022, 122:105711. (SCI, IF=5.275)
2) Dongzhu Duan*, Yanru Wang, Xiaojie Jin, Mi Li, Le Wang, Yunyun Yan, Jian Xiao, Peng Song*, Xiaoling Wang*. Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells. Free Radical Biology and Medicine, 2021, 177:15-23. (SCI, IF=7.376)
3) Dongzhu Duan*, Yanru Wang, Dabo Pan, Le Wang, Jian Xiao, Peng Song*, Xiaojie Jin, Xiaoling Wang*. Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis. Archives of Biochemistry and Biophysics, 2021, 711:109028. (SCI, IF=4.013)
4) Dongzhu Duan*, Xiaolu Feng, Dabo Pan, Le Wang, Yanru Wang, Xiaoling Wang*. Oridonin induces oxidative stress-mediated cancer cells apoptosis via targeting thioredoxin reductase. Current Pharmaceutical Biotechnology, 2022, 23:1647-1657. (SCI, IF=2.837)
5) Junmin Zhang1, Dongzhu Duan1, Alsiddig Osama, Jianguo Fang*. Natural molecules targeting thioredoxin system and their therapeutic potentials. Antioxidants & Redox Signaling, 2021, 34:1083-1107. (1Co-first author, SCI, IF=8.401)
6) Maobo Huang1, Yuanfei Zhou1, Dongzhu Duan1, Chuanyu Yang, Zhongmei Zhou, Fubing Li, Yanjie Kong, Yi-Ching Hsieh, Ruihan Zhang, Wenping Ding, Weilie Xiao, PemaTenzin Puno*, Ceshi Chen*. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib. Cancer Letters, 2021, 504:125-136. (1Co-first author, SCI, IF=8.679)
7) Xin Song, Yanan Guo, Peng Song*, Dongzhu Duan*, Wenjing Guo*. Noncoding RNAs in regulating tumor angiogenesis. Frontiers in Cell and Developmental Biology, 2021, 9:751578. (Corresponding author, IF=6.684)
8) Ruyi Li, Xin Song, Yanan Guo, Peng Song*, Dongzhu Duan*, Zhe-Sheng Chen*. Natural products: A promising therapeutics for targeting tumor angiogenesis. Frontiers in Oncology, 2021, 11:772915. (Corresponding author, SCI, IF=6.244)
9) Zefeng Wang, Qianfei Cui, Ling Shi, Meiling Zhang, Peng Song*, Dongzhu Duan*, Wenjing Guo*. Network Pharmacology-Based Prediction and Verification of Shikonin for the mechanism treating colorectal cancer. Recent Patents on Anti-Cancer Drug Discovery, 2022, 17: 297-311. (Corresponding author, IF=3.083)
10) Junmin Zhang, Dongzhu Duan, Zi-Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang*. Small molecules regulating reactive oxygen species homeostasis for cancer therapy. Medicinal Research Reviews, 2021, 41: 342-394. (SCI, IF=12.944)
11) Dong-Bo Zhang, Zheng Wang, Yan-Ni Liang, Jin-Gao Yu , Zhen Zhang, Shi-Jun Liu, Zhao Zhang, Zhong-Xing Song, Zhi-Shu Tang*, Dongzhu Duan*. Jatrophainolides A-C, new cembrane-type diterpenoids with PTP1Binhibitory activity from the root bark of Jatropha integerrima. Phytochemistry Letters, 2020, 36:166-170. (Corresponding author, SCI, IF=1.679)
12) Junmin Zhang, Dongzhu Duan, Jianqiang Xu, Jianguo Fang*. A redox-dependentcopper carrier promotes cellular copper uptake and oxidative stress-mediatedapoptosis of cancer cells. ACS Applied Materials & Interfaces, 2018, 39:33010-33021. (SCI, IF=9.229)
13) Dongzhu Duan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang* Targeting thioredoxin reductase by parthenolide Contributes to inducing apoptosis of HeLa cells. Journal of Biological Chemistry, 2016, 291:10021-10031. (SCI, IF=5.157)
14) Dongzhu Duan, Baoxing Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge, Shoujiao Peng, Jianguo Fang*. Gambogic acid inducing apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free Radical Biology and Medicine, 2014, 69:15-25. (SCI, IF=7.376)
15) Dongzhu Duan, Baoxing Zhang, Juan Yao, Yaping Liu, Jianguo Fang*. Shikonin targeting the cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells. Free Radical Biology and Medicine, 2014, 70:182-193. (SCI, IF=7.376)
16) Liangwei Zhang, Dongzhu duan, Yaping Liu, Chunpo Ge, Jinyu Sun, Xuemei Cui, Jianguo Fang*. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in Living Cells. Journal of the American Chemical Society, 2014, 136: 226-233. (SCI, IF=14.612)
6. 联系方式
通讯地址：陕西省宝鸡市高新大道1号 宝鸡文理学院化学化工学院
邮编：721013 邮箱: duandongzhu@126.com
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